## Abstract Progression of Parkinson's disease symptoms is imperfectly correlated with positron emission tomography biomarkers for dopamine biosynthetic pathways. The radiopharmaceutical 6‐[^18^F]fluoro‐m‐tyrosine is not a substrate for catechol‐__O__‐methyltransferase and therefore has a more favo
A new precursor for the preparation of 6-[18F]Fluoro-l-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling
✍ Scribed by Henry F. VanBrocklin; Milen Blagoev; Alexander Hoepping; James P. O’Neil; Manuela Klose; Pius A. Schubiger; Simon Ametamey
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 227 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0969-8043
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The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-m-tyrosine derivative 6 with [18F]F2 and [18F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[18F]fluoro-L-m-tyrosine (8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[18F]fluoro-L-m-tyrosine (13a) was
Previous work from this laboratory has shown that the direct fluorination of 3, 4-dihydroxy-phenyl-lalanine (l-DOPA) in anhydrous HF (aHF) or BF 3 /HF with F 2 is an efficient method for the synthesis of 6-fluoro-l-DOPA. Since then, 18 F-labeled 6-fluoro-l-DOPA ([ 18 F]6-fluoro-l-DOPA) has been used