A new potent antifungal agent from Actinoplanes sp

✍ Scribed by Min Chu; Imbi Truumees; Ronald Mierzwa; Joseph Terracciano; Mahesh Patel; Pradip R. Das; Mohindar S. Puar; Tse-Ming Chan

• Book ID: 104259984
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 223 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01696-7

✦ Synopsis

A novel antifungal agent, Sch 56036 (1), was isolated from the fermentation culture broth of an Actinoplanes sp. Structure elucidation of 1 was accomplished by the analysis of spectroscopic data. Compound 1 was identified as a new polycyclic xanthone. Biological evaluation of 1 indicated that the compound possesses broad spectrum antifungal activity against various yeasts and dermatophytes with geometric mean MIC values ranging from 0.017--0.031 gg/mL, respectively.