A new polymer-bound N-hydroxysuccinimidyl active ester linker
β Scribed by Hui Shao; Qiang Zhang; Robert Goodnow; Li Chen; Steve Tam
- Book ID
- 104210365
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 122 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Synthesis of a new N-hydroxysuccinimidyl resin is described and the N-acylation with this resin provides amide products in high yields and excellent purities. This new linker is suitable for combinatorial library synthesis.
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## Abstract __N__βisopropylacrylamide and __N__βacryloxysuccinimide have been copolymerized in various mixtures of terrahydrofuran and toluene using azobisisobutyronitrile as initiator. Polymerization has been conducted for 24 h at 50Β°C under a slightly positive pressure of nitrogen. The copolymers