A new peptidic protease inhibitor from Vicia faba seeds exhibits antifungal, HIV-1 reverse transcriptase inhibiting and mitogenic activities
✍ Scribed by X. Y. Ye; Dr T. B. Ng
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 135 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.425
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✦ Synopsis
Abstract
A new trypsin–chymotrypsin inhibitor, with an N‐terminal sequence showing some differences from the previously reported trypsin–chymotrypsin inhibitor, was isolated from the broad bean Vicia faba. The inhibitor was a peptide with a molecular mass of 13 kDa. It was adsorbed on Affi‐gel blue gel and CM‐Sepharose. It exerted antifungal activity toward Mycosphaerella arachidicola and Physalospora piricola. In addition, the trypsin–chymotrypsin inhibitor elicited a mitogenic response from mouse splenocytes and inhibited the activity of human immunodeficiency virus‐1 reverse transcriptase. Copyright © 2002 European Peptide Society and John Wiley & Sons, Ltd.