A new one-pot solvent-free synthesis of pyridinyl tosylates via diazotization of aminopyridines

✍ Scribed by Alexey N. Tretyakov; Elena A. Krasnokutskaya; Dmitry A. Gorlushko; Vladimir D. Ogorodnikov; Victor D. Filimonov

• Book ID: 104098555
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 334 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.10.163

✦ Synopsis

A new, convenient, one-pot method for the synthesis of pyridinyl tosylates is developed. The procedure involves sequential diazotization/tosylation of aminopyridines with sodium nitrite and p-toluenesulfonic acid under solvent-free conditions in a water paste at room temperature.