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A New Nortriterpene from the Root of Celastrus hypoleucus

✍ Scribed by Hong Wang; Xuan Tian; Guo Qing Ying


Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
182 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

A new nortriterpene, 2‐hydroxy‐3‐methyl‐21‐oxo‐12,24‐dinor‐D : B‐friedooleana‐1,3,5(10),7‐tetraen‐29‐oic acid (1), was isolated from the root of Celastrus hypoleucus, together with the two known compounds, celastorol (2) and pristimerine (3). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 13 exhibited in vitro significant antioxidant (against lipid peroxidation; by the TBARS method) and antitumor activities (against cancer cell lines P‐388, A‐549, HL‐60, and BEL‐7402).


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