A new amino acid derivative with a diol side-chain, L-2-amino-4,5-dihydroxy-pentanoic acid (Adi), has been prepared from L-allylglycine by suitable protection, for use in peptide synthesis, as Fmoc-L-Adi(Trt)2. This building block enables the introduction of a side-chain aldehyde at any position in
✦ LIBER ✦
A new non-natural arginine-like amino acid derivative with a sulfamoyl group in the side-chain
✍ Scribed by Rosaria De Marco; Maria L. Di Gioia; Antonella Leggio; Angelo Liguori; Francesca Perri; Carlo Siciliano; Maria C. Viscomi
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 317 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0939-4451
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## Abstract __The in vitro non‐natural amino acid mutagenesis method provides the opportunity to introduce non‐natural amino acids site‐specifically into proteins. To this end, a chemically synthesised aminoacylated dinucleotide is enzymatically ligated to a truncated suppressor transfer RNA. The l