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A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ

✍ Scribed by Tsuyoshi Saitoh; Chika Shimada; Masatoshi Takeiri; Mitsuhiro Shiino; Shigeru Ohba; Rika Obata; Yuichi Ishikawa; Kazuo Umezawa; Shigeru Nishiyama

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
899 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

The amino-epoxyquinols 6a and 6b were synthesized as soluble derivatives of an NF-κB inhibitor DHMEQ (1). In spite of the opposite configuration from 1, 6b rather than 6a affected the deactivation of NF-κB, based on NO secretion and MALDI-TOF MS analysis. It was indicated that 6b inhibited the activation by different manner from that of 1.

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