A new murine osteoblastic cell line immortalized with the SV40 large T antigen
โ Scribed by Nakamura-Ota, Miki; Hamanaka, Ryoji; Yano, Hiroyuki; Adachi, Sawako; Sumiyoshi, Hideaki; Matsuo, Noritaka; Yoshioka, Hidekatsu
- Book ID
- 125357482
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 520 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1389-9333
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## BACKGROUND. The available human prostate cancer cell lines that are metastatic in athymic nude mice all have complex, highly aneuploid karyotypes. Other prostatic cells immortalized by transforming genes of SV40 or HPV and converted to tumorigenicity by additional genetic manipulation are not r
Clonal cell lines were established from adult rat tibia cells immortalized with SV-40 large T antigen. One clone (TRAB-11), in which retinoic acid (RA) induced alkaline phosphatase (AP) activity, was selected for further study. The TRAB-11 cells express high levels of type I collagen mRNA, type IV c