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A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

✍ Scribed by Didier Coffinier; Laurent El Kaim; Laurence Grimaud; Eelco Ruijter; Romano V.A. Orru

Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
587 KB
Volume
52
Category
Article
ISSN
0040-4039

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A series of 4-aryl-3,5-dicyano-2,6-di(3 0 -indolyl)pyridine derivatives were synthesized via a one-pot multicomponent reaction of aromatic aldehydes, 3-cyanoacetyl indoles, and ammonium acetate under microwave irradiation. Particularly valuable features of this method include high yields of products