𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A new molecular mechanism of neuronal nicotinic acetylcholine receptor blockade

✍ Scribed by N. N. Churaev; É. P. Zatsepin; O. I. Dobrotina

Publisher
Springer US
Year
1991
Tongue
English
Weight
302 KB
Volume
111
Category
Article
ISSN
0007-4888

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Neuronal nicotinic acetylcholine recepto
Neuronal nicotinic acetylcholine receptors as a target for the treatment of neuropathic pain
✍ Michael D. Meyer 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 1 views

## Abstract Neuronal nicotinic acetylcholine receptor (nAChR) agonists have been demonstrated to exhibit antinociceptive, antihyperalgesic, and antiallodynic effects across a range of preclinical models of pain. Yet, to date, no drugs have been successfully developed and approved for the treatment

Effects of SIB-1508Y, a novel neuronal n
Effects of SIB-1508Y, a novel neuronal nicotinic acetylcholine receptor agonist, on motor behavior in parkinsonian monkeys
✍ Jay S. Schneider; Anne Pope-Coleman; Maria Van Velson; Frederique Menzaghi; G. K 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 614 KB

## Abstract The potential antiparkinsonian effects of the centrally acting, subtype‐selective neuronal nicotinic acetylcholine receptor agonist (S)‐(7‐)‐‐5‐ethynyl‐3‐(1‐methyl‐2‐pyrrolidinyl)‐pyridine (SIB‐1508Y) was assessed on motor symptoms and disability scale ratings in three monkeys previousl

New Analogues of Epiboxidine Incorporati
New Analogues of Epiboxidine Incorporating the 4,5-Dihydroisoxazole Nucleus: Synthesis, Binding Affinity at Neuronal Nicotinic Acetylcholine Receptors, and Molecular Modeling Investigations
✍ Clelia Dallanoce; Pietro Magrone; Paola Bazza; Giovanni Grazioso; Luca Rizzi; Lo 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 454 KB 👁 1 views

## Abstract magnified image A group of novel 4,5‐dihydro‐3‐methylisoxazolyl derivatives, structurally related to epiboxidine (=(1__R__,4__S__,6__S__)‐6‐(3‐methylisoxazol‐5‐yl)‐7‐azabicyclo[2.2.1]heptane), was prepared __via__ 1,3‐dipolar cycloaddition of acetonitrile oxide to different olefins. Ta

Alpha7 nicotinic acetylcholine receptor
Alpha7 nicotinic acetylcholine receptor agonists: Prediction of their binding affinity through a molecular mechanics Poisson–Boltzmann surface area approach
✍ Giovanni Grazioso; Andrea Cavalli; Marco De Amici; Maurizio Recanatini; Carlo De 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 479 KB

## Abstract A group of agonists for the α7 neuronal nicotinic acetylcholine receptors (nAChRs) was investigated, and their free energies of binding Δ__G__~bind~ were calculated by applying the molecular mechanics Poisson–Boltzmann surface area (MM‐PBSA) approach. This method, based on molecular dyn