A new model for the quantitative description of the nephrogram

✍ Scribed by F.R.L. Cantraine; P. Bergmann; M. Geens; A. Lenaers; K. Jank; H. Cleempoel

• Publisher: Elsevier Science
• Year: 1972
• Tongue: English
• Weight: 932 KB
• Volume: 5
• Category: Article
• ISSN: 0010-4809
• DOI: 10.1016/0010-4809(72)90005-5

✦ Synopsis

We present a new model of the isotopic nephrogram which is well suited to the study of the kidney when the uptake of radiohippuran is incomplete, i.e., in many clinical situations. By introducing the arteriovenous and arteriourinary weighting functions into the model, the evolution of the nephrogram can be understood in its three phases.

We show that for the explanted kidney, before urinary excretion of hippuran has begun, the nephrogram is completely determined by the curve of arterial concentration and the vascular retention of radioactivity. We propose a way of taking into account urinary excretion and the radioactivity of surrounding tissues so that the model will completely simulate the clinical nephrogram.