A new model for coenzyme B12 based on a Costa-type ligand

✍ Scribed by R. Altink; B. van Arkel; J. L. van der Baan; S. Balt; M. W. G. De Bolster; R. J. van Delft; G. W. Klumpp; H. De Koning; Y. van den Winkel

• Book ID: 104589639
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 612 KB
• Volume: 113
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19941130604

✦ Synopsis

Abstract

The synthesis of a new Costa‐type ligand (H~2~mdo), in which the propylene bridge has been replaced by a methylenedioxy bridge has been accomplished: two molecules of butanedione monoxime are coupled via a CH~2~ group by reaction with CH~2~Cl~2~ and 50% aqueous NaOH in the presence of a phase‐transfer reagent. Dihalidocobalt and alkyl(halido)cobalt complexes of the deprotonated ligand have been prepared and structurally characterized by NMR spectroscopy.