Contribution of the murine mdr1a P-glyco
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Johan W. Smit; Alfred H. Schinkel; Michael MΓΌller; Betty Weert; Dirk K. F. Meije
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Article
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1998
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John Wiley and Sons
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English
β 129 KB
In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta