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A new method to measure intestinal activity of P-glycoprotein in avian and mammalian species

✍ Scribed by Adam K. Green; David M. Barnes; William H. Karasov


Book ID
106044079
Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
316 KB
Volume
175
Category
Article
ISSN
0174-1578

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Contribution of the murine mdr1a P-glyco
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In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta