A new method to characterize saturation functions by their first four moments
✍ Scribed by J.M. Boeynaems; F.R.L. Cantraine
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 644 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0003-2697
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✦ Synopsis
The calculation of the first four moments of saturation functions is proposed as a method to describe the properties of enzymes or receptors models. The values of these moments in the case of the Langmuir or Michaelis-Menten equation and the Hill equation are reviewed. They have been calculated for the second degree Adair equation and in the case of binding site heterogeneity. A method for generalization to cases of greater complexity is also proposed. The advantage of this method over the classical ones--graphical representations and derivation of coefficients like nH, [L]0.9/[L]0.1 ...--is essentially that the moments are defined by one single value independently of any particular model for the whole of the saturation curve.