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A new method for the synthesis of peptides using the adducts of phosphorus compounds and tetrahalomethanes

โœ Scribed by Shun-ichi Yamada; Yoshio Takeuchi

Publisher
Elsevier Science
Year
1971
Tongue
French
Weight
193 KB
Volume
12
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

It has been known that the carboxylic acids are converted to the corresponding acid halides by treatment with the aaduct of triphenylphosphine and carbon tetrachloride 1) or bromine. 2) Recently, Barstow and Hruby reported a simple method for the synthesis of amides using triphenylphosphine and bromotrichloromethane.3) They also briefly tested the possibility of using this method for the synthesis of peptides. However, they neither examined the racemization test under fragment condensation nor synthesized di-or tripeptides except for Z-Phe-Gly-OEt.

Hruby's report prompted us to communicate our results.

We had already investigated a new method for the synthesis of peptides using the adducts of phosphorus compounds (RsP) and tetrahalomethanes (CXI,), and had found reaction

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