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A new method for the synthesis of 4H-1,3,4-thiadiazino[5,6-b]quinoxalines

✍ Scribed by Yoshihisa Kurasawa; Masae Sekine; Ho Sik Kim; Yoshihisa Okamoto


Book ID
112131697
Publisher
Journal of Heterocyclic Chemistry
Year
1996
Tongue
English
Weight
281 KB
Volume
33
Category
Article
ISSN
0022-152X

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## Abstract The reaction of the 6‐chloro‐2‐(1‐methyl‐2‐thiocarbamoylhydrazino)quinoxaline 4‐oxides 3a‐d with trifluoroacetic anhydride gave the 2‐(__N__‐aryl)trifluoroacetamido‐8‐chloro‐4‐methyl‐4__H__‐1,3,4‐thiadiazino‐[5,6‐__b__]quinoxalines 7a‐d, respectively, while the reflux of compounds 3a‐c

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## Abstract The reaction of 6‐chloro‐2‐(1‐methylhydrazino)quinoxaline 4‐oxide 8 with acetic anhydride resulted in the intramolecular cyclization to give 8‐chloro‐2,4‐dimethyl‐4__H__‐1,3,4‐oxadiazino[5,6‐__b__]quinoxaline 7a, while the reaction of compound 8 with acetic anhydride/pyridine or acetic