A new method for the preparation of gelatin nanoparticles: Encapsulation and drug release characteristics

✍ Scribed by B. Vijaya Kumar Naidu; Allan T. Paulson

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 293 KB
• Volume: 121
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/app.34171

✦ Synopsis

Abstract

A new and simple method was developed to produce gelatin nanoparticles of ∼ 30–40 nm for use as carriers for drug release applications. The nanoparticles were uniform in size and well dispersed. An anticancer drug, 5‐fluorouracil, was encapsulated with an efficiency as high as 85%. The nanoparticles showed sustained release of 5‐fluorouracil, and release rates varied with amount of crosslinking in the nanoparticles. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011.