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A new method for the mild and selective reduction of aryl nitro groups on solid support

✍ Scribed by Anitha Hari; Benjamin L. Miller

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 164 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02330-2

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✦ Synopsis

An efficient method for the solid-phase reduction of aryl nitro groups to anilines is described• Among the several reagents tried, chromium chloride was found to be most effective for this reaction. For the substrates examined, reduction occurs in high yield regardless of the substitution pattern on the aromatic ring, and without affecting other reducible functionality.

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