A New Method for Synthesis of 7-Deoxytaxane Analogues by Hydrogenation of Δ6,7-Taxane Derivatives.
✍ Scribed by Yasuyuki Takeda; Toshiharu Yoshino; Kouichi Uoto; Hirofumi Terasawa; Tsunehiko Soga
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 138 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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We have developed an efficient and convenient strategy for the regioselective synthesis of new conformationally restricted butyrophenones of the quinoline series. The 7-aminomethyl-7,8-dihydro-6Hquinolin-5-ones 9 were obtained from protected alcohol 5 via the tosylate, and also in a one-pot reaction