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A new method for protection of carbonyl compounds as 5-methylene-1,3-dioxanes

✍ Scribed by E.J. Corey; J.William Suggs

Book ID
104224406
Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
183 KB
Volume
16
Category
Article
ISSN
0040-4039

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✦ Synopsis

In the course of synthetic studies under way in these Iaboratcries, the need arose for a carbonyl protecting group which could be selectively removed under mild conditions and which itself introduced no new asymmetric centers. Our previous experience with protecting groups cleavable by transition metal reagents' suggested that carbonyl groups when protected as 5-methylene-1,3-dioxanes would be stable to most reagents which attack carbonyl groups &.g., AlHi, BHL, RLi) and that deprotection could be

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