Translational diffusion measurements are a useful tool for where g is the gyromagnetic ratio, d the gradient duration, studying supramolecular complexes and for characterizing the as-G the gradient strength, and D the interval between PFG sociation state of molecules that aggregate at NMR concentrations. pulses.
Pulsed field gradients can be used to measure diffusion coefficients.
Problems related to the practical implementation of the Spectral overlap problems in complex mixtures can be alleviated basic gradient echo experiments include J modulation due by using 2D spectroscopy but the need to record a complete series to homonuclear coupling and residual eddy currents leading of 2D spectra with increasing gradient strength makes these experto phase distortions. Additionally, T 2 relaxation in large moliments extremely time consuming. Concerted incrementation of ecules may be short compared to the interval between PFG the gradient strength and the evolution time provides a new version of accordion spectroscopy that allows the measurement of pulses (D), causing signal decay independent of diffusion individual diffusion coefficients in complex mixtures in a single (4). Finally, spectral overlap poses serious limitations in the experiment. α§ 1998 Academic Press extraction of individual diffusion coefficients in complex Key Words: Accordion spectroscopy; constant time; diffusion; mixtures. The stimulated echo experiment (STE) (5) was DOSY; pulsed field gradients.