A new method for deprotection of benzothiazolesulfonamides using a thiol and base

✍ Scribed by Peter G.M. Wuts; Rui Lin Gu; Northuis M. Jill; Collette L. Thomas

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 108 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)02107-8

✦ Synopsis

Benzothiazolesulfonamides of primary and secondary amines are efficiently cleaved by a nucleophilic aromatic substitution with a thiol and a base such as potassium t-butoxide or diisopropylethyl amine in DMF.