A new synthesis of 1,2,4-triazolin-5-one
โ
Cameron J Cowden; Robert D Wilson*; Brian C Bishop; Ian F Cottrell; Antony J Dav
๐
Article
๐
2000
๐
Elsevier Science
๐
French
โ 82 KB
Chlorotriazolinone 4 has been synthesised in a single step via the novel condensation of semicarbazide hydrochloride with orthoester 8. Alkylation of secondary amine 3 with compound 4 proceeds in 99% yield to afford the target NK 1 antagonist 1.