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A new mesoionic species in the synthesis of some 5-thioxo-1,2,4-triazolin-3-ones

โœ Scribed by S. D. Ziman


Book ID
112126165
Publisher
Journal of Heterocyclic Chemistry
Year
1980
Tongue
English
Weight
63 KB
Volume
17
Category
Article
ISSN
0022-152X

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๐Ÿ“œ SIMILAR VOLUMES


A new synthesis of 1,2,4-triazolin-5-one
โœ Cameron J Cowden; Robert D Wilson*; Brian C Bishop; Ian F Cottrell; Antony J Dav ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 82 KB

Chlorotriazolinone 4 has been synthesised in a single step via the novel condensation of semicarbazide hydrochloride with orthoester 8. Alkylation of secondary amine 3 with compound 4 proceeds in 99% yield to afford the target NK 1 antagonist 1.