A new mechanism — key for an improved synthesis of 2,6-di-tert-butylphenol
✍ Scribed by Friedrich-Wilhelm Küpper
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 135 KB
- Volume
- 264
- Category
- Article
- ISSN
- 0926-860X
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## Abstract For Abstract see ChemInform Abstract in Full Text.
An improved synthesis of 1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the synthesis of an effective HMG-CoA reductase inhibitor atorvastatin, is described. The synthesis is based on the iodolactonization of hepta-1,6-dien-4-ol to 4-allyl-6-iodomethyl-1,3
## Abstract Convenient procedures for the synthesis of functionalized mono‐ and bisphosphinates with 2,6‐di‐tert‐butyl‐4‐methylphenol (ionol) fragments, starting from the available 3,5‐di‐tert‐butyl‐4‐benzaldehyde and its derivatives, are proposed, and some properties of the new phosphorus‐substitu