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A New LC–MS–MS Method for Quantitative Analysis of Adefovir, and Its Use for Pharmacokinetic Studies in Healthy Chinese Volunteers

✍ Scribed by Hai-Tang Xie; Guang-Ji Wang; Mei-Juan Xu; Yuan-Wei Jia; Hao Li; Jian-Guo Sun; Peng Li


Book ID
111791906
Publisher
Springer
Year
2010
Tongue
English
Weight
506 KB
Volume
71
Category
Article
ISSN
0009-5893

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## Abstract A rapid, simple and validated liquid chromatography coupled to tandem mass spectrometric method (LC‐MS/MS) for topiramate analysis in human plasma has been applied to pharmacokinetic and bioequivalence studies in 24 healthy male Korean volunteers. The procedure involves a simple liquid