A New Isofuranonaphthalenone and Benzopyrans from the Endophytic Fungus Nodulisporium sp. A4 from Aquilaria sinensis

✍ Scribed by Zheng-Chao Wu; Dong-Li Li; Yu-Chan Chen; Wei-Min Zhang

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: German
• Weight: 158 KB
• Volume: 93
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900307

✦ Synopsis

Abstract

A new isofuranonaphthalenone, (7__R__*,8__S__*)‐3,6,7,8‐tetrahydro‐4,7,8‐trihydroxynaphtho[2,3‐c]furan‐5(1__H__)‐one (1), and a new benzopyran, (2__R__*,4__R__*)‐3,4‐dihydro‐4‐methoxy‐2‐methyl‐2__H__‐1‐benzopyran‐5‐ol (2), together with four known related analogs, 3–6, were isolated from the culture of Nodulisporium sp. A4, an endophytic fungus from the stem of Aquilaria sinensis (Lour.) Gilg. The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. The isolated compounds 1–6 were evaluated for their cytotoxic activities against the NCI‐H460 and SF‐268 tumor cell lines.