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A new irreversible inhibitor of soybean lipoxygenase; relevance to mechanism

✍ Scribed by E.J. Corey; Marc d'Alarcao; Seiichi P.T. Matsuda

Book ID: 104218935
Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 234 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)84855-8

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✦ Synopsis

The mechanism of the oxidation of arachidonic acid bv sovbean liooxvaenase has been studied kinetically with the help of a newly designed Inhibitor.

It is proposed that olefmcomplexation with Fe(II1) activates arachidonic acid for deprotonation by a basic group on the enzyme leading to an intermediate which then combines with dioxygen.

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