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A New Highly Versatile Handle for Chemistry on a Solid Support: The Pipecolic Linker

✍ Scribed by Paweł Zajdel; Gaël Nomezine; Nicolas Masurier; Muriel Amblard; Maciej Pawłowski; Jean Martinez; Gilles Subra


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
609 KB
Volume
16
Category
Article
ISSN
0947-6539

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Solid phase synthesis of C-terminal pept
✍ Chinh T. Bui; Andrew M. Bray; Thao Nguyen; Francis Ercole; N. Joe Maeji 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB 👁 2 views

A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th