A new highly stereoselective construction of the sidechain of squalamine through improved Sharpless catalytic asymmetric dihydroxylation

✍ Scribed by Xiang-Dong Zhou; Feng Cai; Wei-Shan Zhou

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 81 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00191-5

✦ Synopsis

A new highly stereoselective construction of the sidechain of squalamine has been achieved by using methyl-3-keto-5achenodeoxycholanate (2) as the starting material and an improved Sharpless catalytic asymmetric dihydroxylation as the key step.