A new general synthesis of isomeric nucleosides

✍ Scribed by Sanjib Bera; Vasu Nair

• Book ID: 104231179
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 59 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01118-2

✦ Synopsis

An efficient new method for the synthesis of isonucleosides is described. The key step in the synthesis was the direct coupling of purine and pyrimidine bases with the cyclic sulfate of a carbohydrate intermediate. This reaction proceeded with high regiospecificity and stereospecificity.