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A new general regiocontrolled synthesis of anthracyclinones using cycloaddition of homophthalic anhydrides to 2-chloro-6-oxo-5,6,7,8-tetrahydro-1,4-naphthoquinone 1,2-ethanediyl acetal

✍ Scribed by Tamura, Yasumitsu; Wada, Akimori; Sasho, Manabu; Fukunaga, Keiko; Maeda, Hatsuo; Kita, Yasuyuki


Book ID
126163091
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
355 KB
Volume
47
Category
Article
ISSN
0022-3263

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Two new natural products, N- (2-methyl-3-oxodec-8-enoyl)corresponding acid chloride, in order to acylate Meldrum's acid. Subsequent aminolysis with pyrrolidine, followed by 2-pyrroline (2) and 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8atetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (3), have been methylation