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A new gating site in human aquaporin-4: Insights from molecular dynamics simulations

✍ Scribed by Alberga, Domenico; Nicolotti, Orazio; Lattanzi, Gianluca; Nicchia, Grazia Paola; Frigeri, Antonio; Pisani, Francesco; Benfenati, Valentina; Mangiatordi, Giuseppe Felice


Book ID
127387387
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
1009 KB
Volume
1838
Category
Article
ISSN
0005-2736

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## Abstract Peptide insertion, positioning, and stabilization in a model membrane are probed via an all‐atom molecular dynamics (MD) simulation. One peptide (WL5) is simulated in each leaflet of a solvated dimyristoylglycero‐3‐phosphate (DMPC) membrane. Within the first 5 ns, the peptides spontaneo