A New Fragmentation Reaction of 20-Chloro-16β-hydroxy Steroids

Preparation of 17β-(Hydroxymethyl)-3-met

Preparation of 17β-(Hydroxymethyl)-3-methoxyestra-1,3,5(10)- trien-18-oic Acid 18,20-Lactone, a New C(18)-Oxygenated Steroid

✍ Alexander Kuhl; Wolfgang Kreiser 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 German ⚖ 114 KB

Lactone 13 was synthesized by intramolecular radical-mediated oxygenation of the angular Me(18) group of the 17b-configurated sterol 3. Several substrate-controlled methods for stereoselective construction of the hydroxymethyl side chain of 3 were investigated. Helvetica Chimica Acta ± Vol. 81 (199