A New Ferulic Acid Ester, a New Ellagic Acid Derivative, and Other Constituents from Pachycentria formosana: Effects on Neutrophil Pro-Inflammatory Responses

✍ Scribed by Jui-Ying Cho; Tzong-Huei Lee; Tsong-Long Hwang; Sheng-Zehn Yang; Ih-Sheng Chen; Tsung-Hsien Chou; Ping-Jyun Sung; Jih-Jung Chen

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 328 KB
• Volume: 8
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.201000228

✦ Synopsis

Abstract

A new ferulic acid ester derivative, tetracosane‐1,24‐diyl di[(Z)‐ferulate] (1), and a new ellagic acid derivative, 3,4 : 3′,4′‐bis(O,O‐methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3‐epibetulinic acid (9) exhibited potent inhibition (IC~50~ values ≤21.8 μM) of O~2~^⋅−^ generation by human neutrophils in response to N‐formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine/cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3‐O‐[(E)‐feruloyl]ursolic acid (8), 3‐epibetulinic acid (9), and lawsonic acid (10) also inhibited fMLP/CB‐induced elastase release with IC~50~ values ≤18.6 μM.