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A new expedient route to 2,6-diaryl-3-cyano-4-(trifluoromethyl)pyridines

✍ Scribed by Yoshihiro Yamaguchi; Isamu Katsuyama; Kazumasa Funabiki; Masaki Matsui; Katsuyoshi Shibata

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
407 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

1‐Aryl‐4,4,4‐trifluoro‐1,3‐butanediones 1 react with β‐amino‐β‐arylacrylonitrile 2, readily available from acetonitrile with aryl nitriles in the presence of potassium t‐butoxide, to afford the corresponding 2,6‐diaryl‐3‐cyano‐4‐(trifluoromethyl)pyridines 3 in moderate to excellent yields.

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A new route to 5-trifluoromethyl-2,3-dih
A new route to 5-trifluoromethyl-2,3-dihydro-1,4-diazepine and 2-trifluoromethylbenzimidazole
✍ Shizheng Zhu; Qianli Chu; Yanli Wang πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 165 KB πŸ‘ 1 views

Ethylenediamine reacted readily with 4ethoxy-1,1,1-trifluoro-3-butene-2-one to form 5-trifliuoromethyl-2,3-dihydro-1,4-diazepine in good yield. Under the same reaction conditions, o-phenylenediamine gave 2-trifluoromethylbenzimidazole and benzimidazole.