A new entry to β-hydroxyphosphonates: the SmI2-mediated reaction of diethyl iodomethylphosphonate with carbonyl compounds
✍ Scribed by Fulvia Orsini; Alessandro Caselli
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 93 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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In the presence of samarium iodide diethyl iodomethylphosphonate reacts with esters to afford b-ketophosphonates. The protocol has been applied to sugar lactones to afford in fairly good yields intermediates that are useful precursors for a variety of potentially bioactive compounds, such as the C-g
## Abstract Palladium‐catalyzed tandem reactions of β‐(2‐bromophenyl)‐α,β‐unsaturated carbonyl compounds with 2‐hydroxyphenylboronic acid for the synthesis of benzo[__c__]chromenes are presented. This mild reaction allows formation of onecarbon–carbon bond and one carbon–oxygen bond in one pot.