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A new entry to nucleoside phosphorofluoridate and nucleoside phosphorofluoridothioate diesters

✍ Scribed by Martin Bollmark; Rula Zain; Jacek Stawiński


Book ID
103404649
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
243 KB
Volume
37
Category
Article
ISSN
0040-4039

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The reaction of 5 -protected ribonucleosides with diphenyl H-phosphonate in pyridine furnished rapid formation of the corresponding 2 ,3 -cyclic H-phosphonates 3, which upon sulfurisation and the subsequent removal of the 5protecting group, afforded nucleoside 2 ,3 -O,O-cyclophosphorothioates 5 in h