A convenient simple route to N-unsubstituted B-lactams is described. Formation of unusual N-styryl--B-lactams is the key of the method. Synthesis of N-unsubstituted B-lactams have received increased attention in the past few years and specially with the advent of the third generation of 8-lactam ant
A new entry to N-unsubstituted β-lactams through a solid-phase approach
✍ Scribed by Swapan K. Dasgupta; Bimal K. Banik
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 87 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A remarkable new entry to N-unsubstituted b-lactams using rink resin as the solid-support has been developed.
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## Abstract An operationally simple and efficient approach for the synthesis of novel spiro‐β‐lactams is described. The key reaction is a halogen‐mediated intrasulfenyl cyclization of a __cis__‐3‐benzylthio‐3‐(prop‐2‐ynyloxy/‐enyloxy)‐β‐lactam procured through a Lewis acid‐mediated C‐3‐alkylation o