A new efficient synthesis of alkyl substituted Δ2-butenolides
✍ Scribed by Felix S Pashkovsky; Yadviga M Katok; Tatyana S Khlebnicova; Fedor A Lakhvich
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 59 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A new three-step route to 2-alkyl substituted D 2 -butenolides from 3-alkyltetronic acids is described.
📜 SIMILAR VOLUMES
The structural unit of y-alkylidene-A c,B -butenolide occurs in a variety of natural products, such as patulin, 1) protoanemonin, 2) tetrenolin, 3) freelingyne, 41 and matricarialactone, 5) possessing a wide range of biological activity. This
The d-butenolide function occurs widely in nature as part of a fused ring system such as that of eremophilenolide (1) or as a separate ring in many of the physiologically important cardiac-glycosides (2). Although a large nmnber of synthetic approaches have been reported (3)\_for d-butenolide format
## Abnticx : A MW 6ynthend 04 ~2-buttnotidti ih de.bcLbcd which .&o&m h.kt&Oh&Lc-Live condenntion 06 an cx-htiyt uteh anion ukth an cu-hetoacefal. Unsaturated five membered ring lactones, butenolides, occur widely in nature and display a wide range of interesting properties (1). Despite the great
## Abstract The paper describes a new general synthesis of α‐substituted δ‐carbolines based on key steps such as metalation, cross‐coupling and cyclization.