A new, efficient and chemoselective one-pot protocol for synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones from aryl aldehyde bisulfite adducts promoted by POCL3

✍ Scribed by Ahmad R. Khosropour; Mohammad M. Khodaei; Seyed J. Hoseini Jomor

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 323 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450308

✦ Synopsis

Abstract

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A one‐pot procedure for the synthesis of 4‐arylidene‐2‐phenyl‐5(4__H__)oxazolones directly from aryl aldehyde bisulfite adducts in the absence of Ac~2~O in good to excellent yields using phosphoryl chloride is reported. In addition, the observed chemoselectivity can be considered as a noteworthy advantage of this method.