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A New Direct Synthesis of Aromatic Amides in the Presence of Triethyl Phosphite and 4-Dimethylaminopyridine.

✍ Scribed by Constantin I. Chiriac; Fulga Tanasa; Marioara Onciu


Book ID
101998255
Publisher
John Wiley and Sons
Year
2006
Weight
15 KB
Volume
37
Category
Article
ISSN
0931-7597

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A new direct synthesis of cinnamic acids
✍ Constantin I Chiriac; Fulga Tanasa; Marioara Onciu πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 132 KB

Cinnamic acids have been prepared in 59-86% yields by a new direct synthesis from aromatic aldehydes and aliphatic carboxylic acids in the presence of sodium borohydride and N-methyl-2-pyrrolidinone (NMP) as solvent, at reflux (185-190Β°C), for 9-12 hours. Without sodium borohydride, this reaction is