✦ LIBER ✦

A New Dihydroagarofuranoid Sesquiterpene from Microtropis fokienensis with Antituberculosis Activity

✍ Scribed by Tsung-Hsien Chou; Ih-Sheng Chen; Ping-Jyun Sung; Chien-Fang Peng; Po-Chuen Shieh; Jih-Jung Chen

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 74 KB
Volume: 4
Category: Article
ISSN: 1612-1872
DOI: 10.1002/cbdv.200790139

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✦ Synopsis

Abstract

A new dihydroagarofuran‐based sesquiterpene, 8‐acetoxymutangin (1), was isolated from the stems of Microtropis fokienensis, together with eight known compounds, including mutangin (2). Their structures were determined through in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, 1 exhibited potent in vitro antituberculosis activity, with an MIC value of 10.0 μg/ml against Mycobacterium tuberculosis 90‐221387, which is considerably better than that of mutangin (2). The activity of 1 lies in the same range as that of the clinic drug ethambutol (MIC 6.25 μg/ml), despite completely different chemical structures, which indicates different modes of action.

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