✦ LIBER ✦
A new determinant, Qa-m208, detected on T lymphocytes and transfected L cells by a Kb-specific monoclonal antibody
✍ Scribed by Margriet Oudshoorn-Snoek; Andrew L. Mellor; Richard A. Flavell; Peter Demand
- Book ID
- 104759352
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 893 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
A Kb-specific monoclonal antibody, 6.3.4, defining a new class I specificity, m208, reacts with some K and D region products and with a Qa determinant present on T lymphocytes but not detectable on thymocytes and B lymphocytes. The strain distribution of reactions indicates that this determinant is controlled by the Qa-Tla region, and shows no concordance with the strain distribution pattern of any of the known Qa antigens. The antibody reacts also with L cells expressing a cloned H-2 b class I gene mapping in the Qa-Tla region.