A New, Convenient Synthesis of 1,6-Diaryl-2-thioxoperhydro-4-pyrimidinones: Reaction of 3-Phenyl-2-propenoyl Isothiocyanate With Aromatic and Heteroaromatic Amines
✍ Scribed by Hafez, Ebtisam Abdal Aziz ;Elmoghayar, Mohamed Rifaat Hamza ;Ramiz, Mahmoud Mohamed Mahfouz
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 247 KB
- Volume
- 1987
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
The substituted thioureas 3s -4 prepared from 3-phenyl-2propenoyl isothiocyanate (1) and aromatic or heteroaromatic ' amines 2a-II, cyclize in the presence of sodium ethoxide to give the perhydropyrimidine derivatives 51-c
In conjunction with a project towards development of simple new approaches for the synthesis of heterocycles, the utility of the reaction of 3-phenyl-2-propenoyl isothiocyanate (1) with aromatic and heteroaromatic amines for the synthesis of polyfunctional heterocycles has been investigated 2,3).
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