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A New, Convenient Synthesis of 1,6-Diaryl-2-thioxoperhydro-4-pyrimidinones: Reaction of 3-Phenyl-2-propenoyl Isothiocyanate With Aromatic and Heteroaromatic Amines

✍ Scribed by Hafez, Ebtisam Abdal Aziz ;Elmoghayar, Mohamed Rifaat Hamza ;Ramiz, Mahmoud Mohamed Mahfouz


Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
247 KB
Volume
1987
Category
Article
ISSN
0947-3440

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✦ Synopsis


The substituted thioureas 3s -4 prepared from 3-phenyl-2propenoyl isothiocyanate (1) and aromatic or heteroaromatic ' amines 2a-II, cyclize in the presence of sodium ethoxide to give the perhydropyrimidine derivatives 51-c

In conjunction with a project towards development of simple new approaches for the synthesis of heterocycles, the utility of the reaction of 3-phenyl-2-propenoyl isothiocyanate (1) with aromatic and heteroaromatic amines for the synthesis of polyfunctional heterocycles has been investigated 2,3).


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