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A new class of pyrimidine nucleosides: inhibitors of hepatitis B and C viruses

โœ Scribed by Shakya, Neeraj; Vedi, Satish; Liang, Chao; Agrawal, Babita; Lorne Tyrrell, D.; Kumar, Rakesh


Book ID
122072124
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
537 KB
Volume
22
Category
Article
ISSN
0960-894X

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Recent studies from this laboratory have shown that 6,5'-cyclopyrlmidine nucleosides2, for example the isopropylideneuridine analogue 1, are very susceptible to oxidation at C-5'. Thus, autoxidation3 of 1. with 02-NaOH, or treatment with Mn02 in methanol readily affords the 5'-ketonucleoside 4. The

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