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A New Class of Arylpiperazine Derivatives: the Library Synthesis on SynPhase Lanterns and Biological Evaluation on Serotonin 5-HT 1A and 5-HT 2A Receptors

✍ Scribed by Zajdel, Paweł; Subra, Gilles; Bojarski, Andrzej J.; Duszyńska, Beata; Pawłowski, Maciej; Martinez, Jean


Book ID
126848012
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
153 KB
Volume
6
Category
Article
ISSN
1520-4766

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The synthesis and evaluation as 5-HT 1A and 5-HT 7 serotonin receptor ligands of the two sets of O-substituted hydroxybenzamides, structurally related to 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]pro-poxy}benzamide (1), (K i 5-HT 1A ¼ 21 nM, 5-HT 7 ¼ 234 nM) are reported. To affect the affinity for 5-