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A New Ceramide from Suillus luteus and Its Cytotoxic Activity against Human Melanoma Cells

✍ Scribed by Francisco León; Ignacio Brouard; Fernando Torres; José Quintana; Augusto Rivera; Francisco Estévez; Jaime Bermejo

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 174 KB
Volume: 5
Category: Article
ISSN: 1612-1872
DOI: 10.1002/cbdv.200890002

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✦ Synopsis

Abstract

A new phytosphingosine‐type ceramide, suillumide (1), was isolated from the EtOH extract of the basidiomycete Suillus luteus (L.) S. F. Gray, along with ten known compounds: ergosta‐4,6,8(14),22‐tetraen‐3‐one, ergosterol, ergosterol peroxide, suillin, (E)‐3,4,5‐trimethoxycinnamic alcohol, 5__α__,6__α__‐epoxyergosta‐8,22‐diene‐3__β__,7__β__‐diol, (R)‐1‐palmitoylglycerol, ergosta‐7,9(11),22‐triene‐3__β__,5__α__,6__β__‐triol, cerevisterol, and 4‐hydroxybenzoic acid. The structure of 1 was determined on the basis of spectroscopic and mass‐spectrometric analyses, as well as by chemical methods. Compound 1 and its synthetic diacetyl derivative 2 were tested for their cytotoxic activities against the human melanoma cell line SK‐MEL‐1. Both drugs showed IC~50~ values of ca. 10 μM after 72 h of exposure.

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