A new cascade radical reaction for the synthesis of biaryls and triaryls from benzyl iodoaryl ethers

✍ Scribed by David C Harrowven; Michael I.T Nunn; Nicola A Newman; David R Fenwick

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 71 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)02111-0

✦ Synopsis

The paper describes a new method of synthesizing biaryls and triaryls through an intramolecular ipso-substitution reaction initiated by the addition of an aryl radical to a benzyl ether. A tandem variant of the reaction has also been demonstrated. A short synthesis of isoaucuparin 27, a natural product found in the sapwood tissue of Sorbus aucuparia, is also described.