A new C2-symmetric heterobimetallic complex as a promoter for asymmetric Michael addition reactions

✍ Scribed by G. Manickam; G. Sundararajan

• Book ID: 104361250
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 513 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(97)00234-6

✦ Synopsis

A C2-symmetric chiral amino diol (1R,5R)-3-aza-3-benzyl-1,5-diphenyl pentan-1,5-diol [(R,R)-I] has been synthesised by a modified procedure. The heterobimetallic catalyst [I2-AI-Li] obtained by reaction of the amino diol [(R,R)-I] with LiA1H4, promotes asymmetric Michael addition of malonic esters and thiophenols to et,13-unsaturated compounds with high enantiomeric excess. (~) 1997 Elsevier Science Ltd